Evidence map›Paper›PMID 41427369›Full record

ArticlebioRxiv : the preprint server for biology2025

Cohesin Facilitates Nucleosome Invasion by Transcription Factors.

Shane Stoeber, Hengye Chen, Ruo-Wen Chen, Courtney Smith, Sam Becker, Sarah Vinson, Michael G Poirier, Lu Bai

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shane StoeberDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Hengye ChenDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Ruo-Wen ChenOhio State Biochemistry Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.
Courtney SmithDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Sam BeckerDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Sarah VinsonDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.
Michael G PoirierOhio State Biochemistry Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.ORCID 0000-0002-1563-5792
Lu BaiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.

Funding

Mechanism of Chromatin Accessibility, 3D Chromosome Organization, and Their Functions in Gene RegulationR35GM139654 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Lu Bai · 2021 to 2026
$3.8M
Mechanisms of chromatin regulation of transcriptionR35GM139564 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2021 to 2025
$3.6M
NIGMS NIH HHS R35 GM139564NIGMS NIH HHS R35 GM139654
6 · The paper itself

Abstract

Nucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs known as pioneer factors (PFs) can recognize motifs covered by nucleosomes and initiate chromatin opening. PFs also bind nucleosomal substrates with high affinity

Indexed as

Chromatin accessibilityCohesin complexHistone turnoverNucleosome-depleted regionNucleosome remodelingPioneer factorTranscriptions factor

Identifiers

PMID41427369
PMCPMC12712941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.