ArticlebioRxiv : the preprint server for biology2025
Constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The distal convoluted tubule (DCT) and connecting tubule (CNT) are critical for fine-tuning electrolyte reabsorption and maintaining renal homeostasis. While the Hippo pathway effector Yap is known to regulate kidney development, its specific role within the distal nephron segments remains unknown. Methods: To investigate Yap function in the distal nephron segments, we generated a Cre-inducible Results: Lineage tracing showed that Conclusions: Our findings demonstrate that sustained Yap activation in the distal nephron segments disrupts epithelial identity and structure while also exerting non-cell-autonomous effects on nephron patterning, particularly in the proximal tubule. These results underscore the importance of tightly regulated Hippo-Yap signaling in maintaining epithelial integrity and proper nephron segmentation.
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