Evidence map›Paper›PMID 41427323›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals.

Pravrutha Raman, Hana Khan, Janet M Young, Toshio Tsukiyama, Harmit S Malik

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pravrutha RamanDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.ORCID 0000-0002-7435-9425
Hana KhanDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.
Janet M YoungDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.
Toshio TsukiyamaDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.ORCID 0000-0001-6478-6207
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.ORCID 0000-0001-6005-0016

Funding

Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Molecular mechanisms and functions of global chromatin controlR35GM139429 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TOSHIO TSUKIYAMA · 2021 to 2026
$4.6M
Functional consequences of evolutionary innovation in histone repertoiresK99GM149928 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI RAMAN, PRAVRUTHA · 2023 to 2024
$250k
NIGMS NIH HHS K99 GM149928NIGMS NIH HHS R01 GM074108NIGMS NIH HHS R35 GM139429
6 · The paper itself

Abstract

The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. Its regulation is critical in most eukaryotes. EZHIP was recently characterized as a PRC2 inhibitor and 'oncohistone mimic' in mammals. Although

Indexed as

diversifying selectiongametogenesisgene duplicationhistone methyl transferase inhibitorhistone mimicPolycomb Repressive Complex (PRC2)positive selectionpseudogenes

Identifiers

PMID41427323
PMCPMC12713659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.