Evidence map›Paper›PMID 41427321›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX.

Yujuan Cai 蔡毓娟, Dillon E Kunkle, Marcel D Edinbugh, Eric P Skaar, Brandt F Eichman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yujuan Cai 蔡毓娟Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0002-1372-5727
Dillon E KunkleDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232.ORCID 0000-0001-7579-4165
Marcel D EdinbughDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232.
Eric P SkaarDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0001-5094-8105
Brandt F EichmanDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0002-0965-2297

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
The Staphylococcus aureus response to nutrient zinc restriction during infectionR01AI150701 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2020 to 2024
$2.1M
NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI150701
6 · The paper itself

Abstract

Interstrand DNA crosslinks (ICLs) are a highly toxic form of DNA damage. ICL repair in both eukaryotes and bacteria involves unhooking of the two strands by specialized DNA glycosylases. We recently established that the human pathogen

Indexed as

Bacterial pathogenesisDNA repairhost-pathogen interactions

Identifiers

PMID41427321
PMCPMC12715555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.