Evidence map›Paper›PMID 41427306›Full record

ArticlebioRxiv : the preprint server for biology2025

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology.

Richard Drexler, Belgin Yalçın, Rebecca Mancusi, Abigail Rogers, Kiarash Shamardani, Pamelyn J Woo, Alexandre Ravel, Samuel Wu, Yahaya A Yabo, Lisa Steger and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Richard DrexlerDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Belgin YalçınDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Rebecca MancusiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Abigail RogersDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Kiarash ShamardaniDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Pamelyn J WooDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Alexandre RavelDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Samuel WuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Yahaya A YaboDepartment of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany.
Lisa StegerDepartment of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany.
Carlos Alberto Oliveira de Biagi-JuniorDana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, MA, USA.
Costanza Lo CascioDana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, MA, USA.
Robert MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Boris D HeifetsNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1474-0379
Mariella G FilbinDana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, MA, USA.
Dieter Henrik HeilandDepartment of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany.
Karl DeisserothDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KEITH LLOYD LIGON · 2013 to 2026
$33.5M
Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
eDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7M
Targeting the neuronal microenvironment in glioblastomaU19CA264504 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL J ECK · 2021 to 2026
$6.4M
Glioma Circuitry: Bridging Systems Neuroscience and CancerDP1NS111132 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2018 to 2022
$5.7M
Neuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1M
How the 3D Architecture of the Brain Shapes Cancer Cell Fate DecisionsDP2NS127705 · NINDS · DANA-FARBER CANCER INST · PI FILBIN, MARIELLA GRUBER · 2021 to 2024
$2.7M
Neuronal activity-regulated mechanisms of glioma growthR01NS092597 · NINDS · STANFORD UNIVERSITY · PI MONJE-DEISSEROTH, MICHELLE · 2016 to 2021
$2.1M
NCI NIH HHS OT2 CA278688NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA258384NCI NIH HHS T32 CA009302NCI NIH HHS U19 CA264504NIDA NIH HHS P50 DA042012NINDS NIH HHS DP1 NS111132NINDS NIH HHS DP2 NS127705NINDS NIH HHS R01 NS092597
6 · The paper itself

Abstract

High-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we report that serotonergic neurons promote the proliferation of high-grade gliomas throughout the brain. Serotonergic neuronal activity drives circuit-specific increases in high-grade glioma proliferation, calcium transients, and reduced survival. This growth-promoting effect is chiefly mediated by activation of the serotonin (5-hydroxytryptamine; 5HT) receptor 5HT

Identifiers

PMID41427306
PMCPMC12715541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.