Evidence map›Paper›PMID 41427302›Full record

ArticlebioRxiv : the preprint server for biology2025

A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntington's disease.

Seva Kashin, Won-Seok Lee, Tara M McDonald, Kiely Morris, Robert E Handsaker, Curtis Mello, Liv Spina, Nora M Reed, Heather de Rivera, Sri Havya Jana and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Seva KashinBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0008-1432-8249
Won-Seok LeeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8633-4682
Tara M McDonaldBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0006-2367-662X
Kiely MorrisMcLean Hospital, Belmont, MA 02478, USA.ORCID 0009-0001-9646-5122
Robert E HandsakerBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-3128-3547
Curtis MelloBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-1592-4789
Liv SpinaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0004-1862-4361
Nora M ReedBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0408-1568
Heather de RiveraBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0006-9127-9247
Sri Havya JanaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0008-0121-6301
Marina HoganBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0005-8402-9672
Sabina BerrettaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-4057-7766
Steven A McCarrollBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-6954-8184

Funding

Structurally complex genome loci in human populations and human phenotypesR01HG006855 · NHGRI · HARVARD MEDICAL SCHOOL · PI Steven Andrew McCarroll · 2012 to 2026
$8.2M
NHGRI NIH HHS R01 HG006855
6 · The paper itself

Abstract

Huntington's disease (HD) affects two major brain areas - the striatum and cerebral cortex - in ways that differ in timing, severity, and gene-expression changes. For these reasons, and because many cortical neurons project axons to the affected striatal neurons, striatal and cortical atrophy have long been proposed to have distinct mechanisms, with one potentially a secondary consequence of the other. In the striatum, we recently found that neurons degenerate asynchronously as their own huntingtin (

Identifiers

PMID41427302
PMCPMC12713137

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.