ArticlebioRxiv : the preprint server for biology2025
RNY1 partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation to regulate macrophage programming.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
YRNAs are small noncoding RNAs that are abundant in both cells and biofluids. Prior research has shown that the secretion of extracellular YRNAs (exYRNAs) changes in response to inflammatory stimuli. However, the mechanisms by which exYRNA packaging and dynamics in biofluids regulate inflammation remain poorly understood. In this study, we found that one YRNA species, RNY1, increased in airway fluid during allergen-induced lung inflammation and correlated with neutrophil infiltration. Using RNase sensitivity assays and size exclusion chromatography, we determined that RNY1 was present in airway fluid extracellular vesicles (EVs) and ribonucleoproteins (RNPs), while another YRNA species, RNY3, was present only in EVs. Both the EV and RNP-containing fractions of airway fluid had a unique ability to program cellular inflammation. Airway fluid EVs increased expression of an alternative activation program in macrophages including
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.