Evidence map›Paper›PMID 41427288›Full record

ArticlebioRxiv : the preprint server for biology2025

The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages.

Helena J Barr, Sydney K Caldwell, Justin M Reimertz, Constanze Depp, Alec J Walker, Samuel E Marsh, Anushree S Gupte, Maximilian Hingerl, Jasmin Patel, Sang-O Park and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Helena J BarrHarvard Division of Medical Sciences, Graduate Programs in Neuroscience, Immunology, and Biological and Biomedical Sciences, Boston, MA.
Sydney K CaldwellHarvard Division of Medical Sciences, Graduate Programs in Neuroscience, Immunology, and Biological and Biomedical Sciences, Boston, MA.
Justin M ReimertzBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Constanze DeppBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Alec J WalkerHarvard Division of Medical Sciences, Graduate Programs in Neuroscience, Immunology, and Biological and Biomedical Sciences, Boston, MA.
Samuel E MarshBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Anushree S GupteBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Maximilian HingerlBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Jasmin PatelBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Sang-O ParkHarvard Division of Medical Sciences, Graduate Programs in Neuroscience, Immunology, and Biological and Biomedical Sciences, Boston, MA.
Sarah FerraroBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Jonathan LiptonBoston Children's Hospital, Kirby Neurobiology Center, Boston, MA.
Beth StevensHarvard Division of Medical Sciences, Graduate Programs in Neuroscience, Immunology, and Biological and Biomedical Sciences, Boston, MA.

Funding

Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
NIA NIH HHS T32 AG000222
6 · The paper itself

Abstract

Circadian disruptions perturb the brain and immune system and increase the risk of developing Alzheimer's Disease (AD), yet whether this involves dysregulation of brain immunity remains less clear. Here, we perform single-cell RNA sequencing of the brain immune compartment around the day-night cycle and identify brain border-associated macrophages (BAMs) as highly rhythmic cells. During the rest phase, we find that BAMs exhibit coordinated upregulation of endocytic genes and enhanced uptake of extracellular fluid-borne material including amyloid-beta (Aβ). Rhythmicity in BAM scavenging is regulated by the clock gene

Identifiers

PMID41427288
PMCPMC12713129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.