Evidence map›Paper›PMID 41427283›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular interactions of Chd8 in mouse brain highlights a role in chromatin-associated RNA processing.

Emily Smith, Cesar P Canales, Mathew W Kenaston, Nicolas Seban, Ayanna A Wade, Ethan Fenton, Cory Ardekani, Stephanie Lozano, Nickolas C Chu, Daniela Perla and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emily SmithUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0002-8651-9174
Cesar P CanalesUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0003-2505-8367
Mathew W KenastonDepartment of Chemical Engineering, UC Davis, Davis, CA, USA.
Nicolas SebanUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Ayanna A WadeUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Ethan FentonUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Cory ArdekaniUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Stephanie LozanoUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Nickolas C ChuUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Daniela PerlaUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Ksenia MedvedevaUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Kaitlyn McCaffertyUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Yingjing GuoUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Aspen Kopley-SmithUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Abigail IgnasiakUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Dylann CullinaneUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Karol CichewiczUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Gabriela GrigoreanProteomics Core Facility, University of California, Davis, CA, USA.
Priya S ShahDepartment of Chemical Engineering, UC Davis, Davis, CA, USA.ORCID 0000-0001-7518-2839
Alex S NordUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0003-4259-7514

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Causal biology of Chd8 haploinsufficiency in complex brain disordersR01MH120513 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NORD, ALEXANDER · 2019 to 2023
$2.3M
Molecular mechanisms linking viral replication and neuropathogenesisR01AI170857 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Priya Shirish Shah · 2023 to 2026
$2.1M
Mapping the cellular impacts of Chd8 haploinsufficiency and characterizing microglial activity in Chd8 mutant miceF31HD113328 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Stephanie Lozano · 2024 to 2026
$118k
Chd8 Dosage-Sensitivity in Mature Neurons Contributes to ASD-Associated PathologyF31MH119789 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WADE, ALEXANDRIA AYANNA · 2019 to 2020
$56k
NIAID NIH HHS R01 AI170857NICHD NIH HHS F31 HD113328NIGMS NIH HHS T32 GM007377NIMH NIH HHS F31 MH119789NIMH NIH HHS R01 MH120513NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

The chromatin remodeler

Identifiers

PMID41427283
PMCPMC12714018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.