ArticlebioRxiv : the preprint server for biology2025
White-Matter BOLD Mediates Time-Varying Cortico-Cortical Functional Connectivity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Structural and functional anatomy of the superior longitudinal fasciculus: a historical and contemporary narrative review.Anatomical science international · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Functional connectivity (FC) measurements in the brain using BOLD fMRI have largely focused on correlations between gray-matter (GM) BOLD signals, ignoring the possible relevance of white-matter (WM) in delineating neural networks. We first employed a tract-informed mediation framework to test whether WM pathways contribute indirect, bundle-specific effects to cortico-cortical coupling. Using resting-state fMRI data from the Human Connectome Project, we quantified pathway-level mediation effects across GM-WM-GM units and found that WM BOLD signals significantly mediated GM-GM associations, with clear tract-dependent heterogeneity. Building upon this, we examined how dynamic features of WM BOLD signals relate to time-varying intra-cortical FC. We found that temporal variability of WM signals, rather than their mean amplitudes, more closely tracked fluctuations in GM-GM dynamic connectivity, with correlations reaching approximately 0.4 across specific tracts. Together, these results indicate that WM BOLD signals are related to how cortical regions interact, underscoring their integral role in large-scale brain network organization.
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Registered trials
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