Evidence map›Paper›PMID 41427278›Full record

ArticlebioRxiv : the preprint server for biology2025

Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial.

Tae Lee, Jayce Liu, Yeaeun Park, H Liva Rakotondraibe, Xiaolin Cheng, Peter M Piermarini

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tae LeeDepartment of Entomology, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA.
Jayce LiuDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Yeaeun ParkDepartment of Entomology, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA.
H Liva RakotondraibeDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-2166-4992
Xiaolin ChengDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Peter M PiermariniDepartment of Entomology, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA.ORCID 0000-0003-1020-5774

Funding

Developing botanical-derived chemical tools for controlling mosquito vectorsR56AI158674 · NIAID · OHIO STATE UNIVERSITY · PI CHENG, XIAOLIN, PIERMARINI, PETER M · 2022 to 2022
$648k
NIAID NIH HHS R56 AI158674
6 · The paper itself

Abstract

TRPA1 channels are multi-modal receptors in animals for sensing noxious physical and chemical factors. They are considered promising biochemical targets for developing repellents of arthropod disease vectors and drugs to treat a variety of medical conditions including pain, inflammation, and itch. Recently, we discovered that cinnamodial (CDIAL), a natural drimane sesquiterpene produced by the medicinal plant

Identifiers

PMID41427278
PMCPMC12713677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.