ArticleACS omega2025
Design, Synthesis, and Evaluation of β‑Lactamase Inhibitors as Potential Therapeutics for Antimicrobial Resistance.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Essential Oil ofMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a global health threat affecting millions of people worldwide. The situation has been exacerbated by the emergence of β-lactamase enzymes that can hydrolyze the β-lactam rings within the antibiotics. This makes antibiotics incapable of preventing bacterial infections. The abuse of β-lactam antibiotics is instigating bacterial resistance, thus causing the antibiotics to fail. There is a need to develop newer drugs that can tackle these β-lactamases and overcome bacterial infections. Thienopyrimidines have exhibited diverse biological activities as promising potent antibacterial agents. We synthesized a wide array of substituted thienopyrimidines using a highly divergent approach to introduce different groups involving Suzuki and Sonogashira coupling reactions, aromatic nucleophilic substitution, and alkylation reactions. Novel thienopyrimidines were tested against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.