ArticleACS omega2025
Impact of Proteins on the Cellular Uptake of Carbon Nanodots.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Boron-Doped Carbon Dots for Organelle Labeling and Mitochondrial Bioimaging.Methods and protocols · 2026Article
- Development of Chitosan-Carbon Dot Hybrid Nanoemulsomes for MEIS2 Inhibitor Delivery and Bioimaging in Colorectal Cancer.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are many reports in the literature on how a formed protein corona around colloidal nanoparticles affects their uptake by cells. There are however still details to be investigated, such as the role of a preformed protein corona versus the protein corona formed in serum-supplemented culture media, which is the topic of this work. Carbon nanodots (CDs) were preincubated with human serum albumin (HSA), and their cellular uptake was studied with flow cytometry and confocal laser scanning microscopy, in comparison to bare CDs. Measurements were carried out under serum-free and serum-containing conditions, leading to a 2 × 2 sample set: CDs with proteins (HSA preincubation + serum, serum, and HSA preincubation), and CDs without proteins. Serum-supplemented conditions lead to reduced uptake of CDs, whereas preincubation with HSA enhanced their internalization.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.