Evidence map›Paper›PMID 41427165›Full record

ArticleACS omega2025

Antimicrobial Peptide-Loaded Mesoporous Silica Nanoparticles: A pH-Triggered Controlled Release against Biofilms.

Mirena Sakaj, Vincenzo Lombardi, Isabella Caligiuri, Andrea Castellin, Pietro Riello

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mirena SakajDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.ORCID https://orcid.org/0000-0001-7144-2154
Vincenzo LombardiDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.
Isabella CaligiuriPathology Unit Department of Molecular Biology and Translational Research, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, 33081 Aviano ,Italy.
Andrea CastellinBrenta Srl, v.le Milano, 26, Montecchio Maggiore, 36075 Vicenza, Italy.
Pietro RielloDepartment of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Via Torino 155, 30172 Mestre, Italy.ORCID https://orcid.org/0000-0002-6087-3802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid emergence of multidrug-resistant bacteria has intensified interest in antimicrobial peptides (AMPs) as alternative therapeutics due to their potent broad-spectrum activity and low propensity for inducing resistance. However, the clinical translation of AMPs is hindered by their inherent low stability and susceptibility to proteolytic degradation. In this study, we investigated a pH-responsive delivery system using mesoporous silica nanoparticles (MSNs) to encapsulate frog-derived temporin B and scorpion-derived BmKn2two AMPs that have shown particular promiseaiming to enhance their stability and enable targeted eradication of

Identifiers

PMID41427165
PMCPMC12713444

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.