ArticleFrontiers in veterinary science2025
Transcriptome sequencing reveals the key genes associated with hair follicle development in Qianhua Mutton Merino.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Dynamic analysis of skin transcriptome in Xinjiang goats and functional verification ofVeterinary and animal science · 2026Article
- Genetic dissection of leg and back feather follicle density in yellow-feathered broiler: integrative GWAS and transcriptome analysis reveal the regulatory role of SERPINF1.Poultry science · 2026Article
- Transcriptomic Analysis Reveals AKT1 Upregulation in Inner Mongolian Cashmere Goats at 12 and 15 Months of Age.Veterinary sciences · 2026Article
- Comparative Skin Transcriptome Analysis Identifies Candidate Genes Associated with Skin Responses in Hu Sheep Raised Under Different Regional Rearing Conditions.Animals : an open access journal from MDPI · 2026Article
- Comparative Skin Transcriptomics Reveals Key Regulators of Cashmere Fiber Production in Inner Mongolian Goats.Animals : an open access journal from MDPI · 2026Article
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Abstract
Background: The aim is to compare the morphological changes and gene expression profiles of hair follicles in newborn and one-year-old Qianhua Mutton Merino sheep, explore the changes in gene expression and related regulatory pathways during the process from incomplete development to full development of skin hair follicles, and identify the key genes influencing hair follicle development and maturation. This study holds significant theoretical importance for revealing the molecular regulatory mechanism of hair follicle development in Qianhua Mutton Merino sheep. Methods: A total of five newborn (1-day-old) and five yearling (12-month-old) Qianhua Mutton Merino sheep were selected for this study. Skin tissue samples were collected for histological analysis using HE staining. Transcriptome sequencing was performed on the Illumina NovaSeq 6000 platform, and differentially expressed gene (DEG) analysis was conducted using the R package degeR. GO and KEGG pathway enrichment analyses were performed on the DEGs to identify genes associated with hair follicle development. Ten DEGs were randomly selected for the validation of the transcriptome sequencing results using realtime quantitative PCR. The Results: The results from HE staining indicated that with an increase in the age of the Qianhua Mutton Merino sheep, the density of both primary and secondary hair follicles significantly decreased ( Conclusion: In conclusion, this study identified the
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