ArticleSovremennye tekhnologii v meditsine2025
Experimental Study of the Effect of Corneal Bio-Coating Based on the Original Hydrogel Biopolymer Scaffold on the Anterior Segment Structures of the Eye.
Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, there have been proposed various kinds of bioengineering constructions of scaffolds - biomaterial structures serving as substrates for restoration and regeneration of tissues. They possess marked biocompatibility, are capable of supporting high concentration of substances delivered to the injured tissues, and may be standardized in the process of fabrication. Materials and Methods: The experimental study was carried out on 6 rabbits (6 eyes). The original hydrogel biopolymer scaffold of 10.0 mm in diameter, 1.5 and 2.0 mm thick was used as a bio-coating for the cornea. On days 3, 7, and 9 from the beginning of the experiment, the results were histologically tested. Results: On days 3 and 7 of the experiment, histological investigations did not find any structural changes of the anterior segment of the eye and differences between the scaffolds of various thicknesses. The stroma, Descemet's membrane, endothelium, and general topography of the intercellular matrix were not altered. On day 9, structural changes of the anterior segment were not revealed either in the experiment with the 1.5 mm thick scaffold. Histological investigations of the specimen with the 2.0 mm scaffold showed alterations in the form of epithelium thickening, signs of pseudostratified basal layer, hyperplasia of the wing cell layer with the increased number of its layers, greater number of cellular elements in the anterior stroma layers. No structural changes of the Descemet's membrane and corneal endothelium were noted. Conclusion: The suggested hydrogel scaffold-based bio-coating is subject to self-biodegradation without any sequelae to the eye and its adnexa. Increased thickness of the bio-coating results in deceleration of its biodegradation and enhanced activity of proliferative processes in the epithelium and anterior stromal layers, which is indirect evidence of improved regenerative properties of these tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.