Evidence map›Paper›PMID 41427061›Full record

ArticleMaterials today. Bio2025

Porcine decellularized splenic matrix hydrogel-based vesicle sustained-release System: A dual-regulatory biomaterial for accelerated wound healing via angiogenesis and immune remodeling.

Peng Peng, Siyuan Fan, Peisheng Liu, Xiaoyao Huang, Zilin Xuan, Anqi Liu, Meiling Wu, Bingdong Sui, Bin Ye, Sha Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peng PengState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Siyuan FanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Peisheng LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xiaoyao HuangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Zilin XuanFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2050, Australia.
Anqi LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Meiling WuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Bingdong SuiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Bin YeDepartment of Orthopaedic, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Sha ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Hao GuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing involves a complex cascade of regenerative processes, particularly angiogenesis and immunomodulation, the orchestration of which is highly important for efficient repair of tissue defects. However, there is currently a lack of feasible strategies to coordinate angiogenesis and immunomodulation during cutaneous wound management, leading to non-healed skin defects a persistent clinical challenge. In this study, by harnessing the natural immunomodulatory property of splenic matrix and the intrinsic angiogenic effects of apoptotic vesicles (ApoVs), we developed a composite system loading ApoVs derived from stem cells of human exfoliated deciduous teeth (SHED-ApoVs) onto a porcine decellularized splenic matrix-based hydrogel (pDSMG). This pDSMG/SHED-ApoVs system maintains sustainable release of functionalized ApoVs to boost angiogenesis in the early phase of wound healing. Furthermore, the system also preserves the pDSMG capacity of immunomodulation, such as promoting M2 macrophage polarization, Treg differentiation and anti-inflammatory cytokines. With these synergistic effects, pDSMG/SHED-ApoVs creates an optimal regenerative microenvironment and significantly accelerates cutaneous wound healing, which is mechanistically mediated through inhibiting the glycolytic metabolism. Collectively, an innovative bioactive material system of pDSMG/SHED-ApoVs has been established, which safeguards efficient wound healing through concerted actions on angiogenesis and immunomodulation. With translational advantages of pDSMG/SHED-ApoVs, this approach holds potential for clinical wound management.

Indexed as

AngiogenesisApoptotic vesiclesCutaneous wound healingImmune remodelingPorcine decellularized splenic matrix hydrogel

Identifiers

PMID41427061
PMCPMC12712692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.