ArticleFrontiers in endocrinology2025
Association of the inflammatory microenvironment of obesity with pathological complete response in patients with breast cancer receiving neoadjuvant chemotherapy.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The impact of the inflammatory microenvironment at different body mass index (BMI) on pathological complete response (pCR) in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NAC) remains unclear. Methods: We retrospectively analyzed 834 BC patients who received NAC, categorized into low-BMI (BMI < 25) and high-BMI (BMI ≥ 25) groups. We compared the differences in peripheral blood platelet count (P), lymphocyte count (L), neutrophil count (N), and monocyte count (M) using the Wilcoxon test. Additionally, we calculated the dynamic changes in these immune cells (ΔP, ΔL, ΔN, ΔM) based on hematological tests before and after NAC. Receiver operating characteristic (ROC) curves were used to assess the predictive value of peripheral immune cells for pCR. Logistic regression was used to identify independent risk factors associated with pCR. Finally, a nomogram was constructed based on multivariate logistic regression. Results: After standardizing peripheral immune cells, before NAC, the P ( Conclusion: Peripheral immune cells in the inflammatory microenvironment at different BMI groups play an important role in predicting pCR in BC patients receiving NAC.
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