ArticleFrontiers in endocrinology2025
The predictive value of the metabolic score for insulin resistance for metabolism-related disorders and fertility outcomes in Chinese women with polycystic ovary syndrome.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The Limited Diagnostic Utility of Metabolic and Inflammatory Indices in Adolescent Polycystic Ovary Syndrome: A Case-Control Study.Biomedicines · 2026Article
- Assessing the Discriminative Power of Metabolic Indices for PMOS Detection in Normal-Weight Women.International journal of women's health · 2026Article
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13 authors.
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Abstract
Objective: This study aimed to evaluate the predictive value of the Metabolic Score for Insulin Resistance (Mets-IR) for metabolism-related disorders and its association with hormonal status and fertility outcomes in Chinese women with Polycystic Ovary Syndrome (PCOS). Methods: This secondary analysis included 957 women from the PCOSAct trial. Participants were stratified by Mets-IR quartiles. Linear regression analyzed correlations between Mets-IR and metabolic/hormonal parameters. ROC curves assessed Mets-IR's predictive performance for metabolic disorders. Multivariable logistic regression evaluated associations with fertility outcomes. Results: Significant linear correlations were observed between Mets-IR and key metabolic parameters (e.g., HOMA-IR, TG, WHR) and hormonal parameters (PG, E2, FT, LH, FSH, LH/FSH ratio, SHBG, FAI, AMH) (all Conclusion: In women with PCOS, Mets-IR demonstrates significant associations with both metabolic and hormonal parameters and exhibits superior predictive ability over BMI for key hormonal markers (SHBG, FAI, AMH). This index serves as an effective non-invasive predictor for IR, MetS, and NAFLD. For the assessment of ovulatory dysfunction, its predictive performance is comparable to that of BMI, yet it demonstrates no significant association with other fertility outcomes.
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