ArticleHuman mutation2025
Causal Relationships Between Pregnancy, Menstrual History, and Endometrial Cancer With Mediating Effects of Metabolism-Related Traits.
Article in Human mutation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Obesityand Gynaecological Cancers, with a Focus on Morbid Obesity: Risk Stratification, Early Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- From virtual pregnancy to digital twin obstetrics: multimodal data integration for personalized prediction of pregnancy complications.Frontiers in medicine · 2026Review
- Premature placental senescence in early-onset preeclampsia: syncytiotrophoblast SASP and the maternal syndrome.Frontiers in public health · 2026Review
- Causal Relationships Between Pregnancy, Menstrual History, and Endometrial Cancer With Mediating Effects of Metabolism-Related Traits.Human mutation · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periods and pregnancy may affect the development of endometrial cancer by affecting the secretion of sex hormones, but the causal relationship is not clear, and its mediating factors need to be explored. Methods: In this study, multivariable Mendelian randomization was used to analyze summary statistics of genome-wide association studies of European ancestry, to evaluate the effect of 10 period- or pregnancy-related factors on endometrial cancer. In addition, we performed the heterogeneity test and pleiotropy test to analyze the sensitivity. Because of the effect of sex hormones on body metabolism and the relationship between metabolism-related traits and cancer, we explored the mediating effect of metabolism-related traits by two-step Mendelian randomization. Results: This study showed that age at menarche ( Conclusion: This study demonstrated the independent effect of pregnancy- and period-related factors on endometrial cancer and suggested that avoiding obesity may be an effective method to prevent endometrial cancer for patients with premature menarche.
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Registered trials
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