The Original Mouse Models of Glioblastoma: Analysis of Pathophysiological Characteristics of Transplanted Tumor Tissue.

V V Kudelkina, M V Gulyaev, A S Khalansky, E A Miroshnichenko, O V Makarova, T Kh Fatkhutdinov, A M Kosyreva

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Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

V V KudelkinaResearcher, Laboratory of Neuromorphology; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia; Junior Researcher, B.V. Shvyrkov Laboratory of Psychophysiology; Institute of Psychology of the Russian Academy of Sciences, 13, Bldg. 1, Yaroslavskaya St., Moscow, 129366, Russia.

M V GulyaevPhD, Senior Researcher, Laboratory of Magnetic Tomography and Spectroscopy; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.

A S KhalanskyPhD, Collection Specialist; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia.

E A MiroshnichenkoJunior Researcher, Laboratory of Neuromorphology; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia; Junior Researcher, Department of Histology, Cytology, and Embryology; Peoples' Friendship University of Russia named after Patrice Lumumba, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.

O V MakarovaMD, DSc, Professor, Head of the Laboratory of Immunomorphology of Inflammation; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia.

T Kh FatkhutdinovMD, DSc, Associate Professor, Chief Researcher, Laboratory of Growth and Development; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia; Head of the Department of Histology, Cytology, and Embryology; Peoples' Friendship University of Russia named after Patrice Lumumba, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.

A M KosyrevaPhD, Head of the Laboratory of Neuromorphology; Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, 3 Tsurupy St., Moscow, 117418, Russia; Professor, Department of Histology, Cytology and Embryology; Peoples' Friendship University of Russia named after Patrice Lumumba, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: Two new chemically induced, easily transplantable tissue mouse models of high-grade glioma have been created and characterized. M2 GB and M6 GB tissues were orthotopically transplanted to immunocompetent C57BL/6 mice. The clinical and morphological characteristics of tumor growth, as well as the intratumoral immune response and target gene expression were assessed. Results: Clinical manifestations of M2 GB and M6 GB growth in mice include motility disorders, cachexia, and priapism. Morphologically, M2 GB and M6 GB are characterized by diffuse proliferation, cellular and nuclear polymorphism, and high mitotic activity with pathological mitotic patterns corresponding to the aggressive nature of the mentioned tumors. Both tumors were significantly infiltrated with CD3 Conclusion: The M2 GB and M6 GB models of transplanted tissues reproduce key characteristics of human GB, including similar intracellular immune profiles, clinical and morphological features, and gene expression patterns, which are important for further research in neurological oncology. These models can be used to develop diagnostic and treatment methods and to study tumor genesis.

Indexed as

Brain NeoplasmsGlioblastomaAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLgene expressionglioblastoma mouse modelintratumor immune responsemorphology

Identifiers

PMID41426972

DOI10.17691/stm2025.17.5.03

PMCPMC12715489

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