ArticlemicroPublication biology2025
The CCR4-NOT deadenylase complex mediates tubulin autoregulation
Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tubulin autoregulation maintains cellular microtubule homeostasis by triggering rapid degradation of tubulin mRNAs in response to an increase in soluble α- and β-tubulin levels. Through siRNA knock-down of several RNA decay pathways coupled with Roadblock-qPCR kinetic measurements, we independently validate and extend prior work by identifying the CCR4-NOT deadenylase complex components CNOT1, CNOT10, and CNOT11 as central effectors both in tubulin autoregulation and basal tubulin mRNA stability. In contrast, depletion of ribosome quality control and other decay factors has little effect. These findings corroborate CCR4-NOT adaptors as essential effectors of tubulin autoregulation and provide molecular entry points to dissect microtubule homeostasis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.