Evidence map›Paper›PMID 41426946›Full record

ArticleGlomerular diseases

Evaluating the Potential Role of Corticosteroids in Post-Infectious Glomerulonephritis.

Theerachai Thammathiwat, Talerngsak Kanjanabuch, Athiphat Banjongjit, Suwasin Udomkarnjananun, Kroonpong Iampenkhae, Jerasit Surintrspanont, Somchai Eiam-Ong, David W Johnson

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Article in Glomerular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Theerachai ThammathiwatDivision of Nephrology, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Talerngsak KanjanabuchPeritoneal Dialysis Excellent Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Athiphat BanjongjitNephrology unit, Department of Medicine, Vichaiyut Hospital, Bangkok, Thailand.
Suwasin UdomkarnjananunDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Kroonpong IampenkhaeDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jerasit SurintrspanontDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Somchai Eiam-OngDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
David W JohnsonDepartment of Kidney and Transplant Services, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Corticosteroids are commonly used in severe post-infectious glomerulonephritis (PIGN), but the optimal dosing and long-term outcomes remain unclear. This study investigated the association between cumulative corticosteroid dosage and mortality in patients with biopsy-proven PIGN. Methods: This retrospective cohort study included adult patients (≥18 years) with biopsy-proven PIGN from the King Chulalongkorn Memorial Hospital registry (1996-2023), excluding those with concurrent infections or conditions affecting prognosis. Clinical and histopathological data were collected. The primary outcome was kidney failure (estimated glomerular filtration rate of <15 mL/min/1.73 m Results: Among 7,005 kidney biopsies, 73 patients with PIGN were analyzed. Over a median follow-up of 15.6 years, 15% died and 15% developed kidney failure. Steroids were used in 62% of patients and were associated with higher rate of skin/soft tissue infections (26% vs. 11%, Conclusion: Corticosteroids improve survival in PIGN, but cumulative doses ≥73 mg/kg increase mortality risk. Low-dose corticosteroids may be beneficial in severe PIGN, but further research is needed to refine dosing strategies.

Indexed as

Corticosteroid therapyGlomerulonephritisMortality predictionPost-infectious glomerulonephritisPrednisolone dosage

Identifiers

PMID41426946
PMCPMC12717674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.