Evidence map›Paper›PMID 41426875›Full record

ArticleCureus2025

Infliximab-Induced Autoimmune Phenomenon in an Adolescent With Ulcerative Colitis: Drug-Induced Lupus vs Inflammatory Myositis.

Nika Bakshi, Maya S Kardouh, Jamal Kriem

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nika BakshiMedicine, Oakland University William Beaumont School of Medicine, Rochester, USA.
Maya S KardouhInternal Medicine, Oakland University William Beaumont School of Medicine, Rochester, USA.
Jamal KriemPediatric Gastroenterology, Beaumont Health, Royal Oak, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 15-year-old female with ulcerative colitis who developed an asymptomatic rise in creatine kinase and transaminases while on infliximab therapy. Additional rheumatologic workup revealed high-titer anti-nuclear antibody and positive anti-histone antibody, with the absence of myositis-specific autoantibodies. A drug-induced autoimmune phenomenon was suspected, with the patient lacking any muscle weakness or lupus features. The patient was subsequently switched to ustekinumab, which resulted in complete normalization of her labs while maintaining remission of her ulcerative colitis.

Indexed as

autoimmune adverse eventsinflammatory bowel diseaseinfliximabmyositisulcerative colitis

Identifiers

PMID41426875
PMCPMC12715295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.