ArticleCureus2025
Cholestatic Jaundice as the Initial Manifestation of Classical Hodgkin Lymphoma: A Diagnostic Challenge.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Hodgkin lymphoma (HL) is a cancer of the lymphatic system that typically presents with systemic B symptoms and lymphadenopathy, while hepatic involvement is rare, and initial presentation with liver dysfunction is uncommon. We report a case of a 47-year-old patient who presented with progressive jaundice and generalized weakness. His clinical course and laboratory findings suggested multiple possible causes, and due to diagnostic uncertainty, a liver biopsy was performed, revealing Hodgkin and Reed-Sternberg cells consistent with classical HL. This case highlights a rare initial hepatic presentation of HL manifested as cholestatic jaundice and underscores the importance of considering infiltrative malignancies in the differential diagnosis of unexplained liver dysfunction, as well as the critical role of liver biopsy when noninvasive evaluations fail to provide a conclusive diagnosis.
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