ArticleCureus2025
Clinical Spectrum, Etiology, and Complications of Liver Cirrhosis at a Tertiary Care Center in Western India: An Observational Clinic-Based Cohort Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Trends in the global burden of anemia associated with liver cirrhosis: an assessment from 1990 to 2021 and projections to 2045.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis, a major global health burden, often presents at a decompensated stage. This study aimed to describe the clinical profile, etiology, and complications of liver cirrhosis at a tertiary care center in Western India, with a focus on identifying treatable causes.
methodsThis observational cohort study was conducted at the Department of Medicine, Gujarat Medical Education and Research Society (GMERS) Medical College and Hospital, Sola, Ahmedabad, between June 1, 2022, and May 31, 2024. One hundred consecutive patients with cirrhosis were enrolled. The study design included an initial cross-sectional analysis at patient presentation and a subsequent one-year prospective follow-up to monitor complications. Data on demographics, clinical presentation, etiology, laboratory parameters, and complications were collected and analyzed using descriptive statistics. The study has been reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology
resultsThe mean age was 52.4±14.3 years, with a male predominance (71%; n=71). The most common etiologies were alcohol (66%; n=66), hepatitis B virus (12%; n=12), and non-alcoholic steatohepatitis (11%; n=11). The majority of patients (65%; n=65) had Child-Pugh Class C disease. Common presenting features included abdominal swelling (68%; n=68), jaundice (65%; n=65), and ascites (68%; n=68). Prevalent laboratory abnormalities included anemia (67%; n=67), thrombocytopenia (61%; n=61), hypoalbuminemia (76%; n=76), and an elevated international normalized ratio (INR) (65%; n=65). During follow-up, recurrent ascites (44.6%; n=41 of 92 episodes) was the most common complication leading to readmission. A significant association was found between Child-Pugh Class C and the development of acute kidney injury during follow-up (p<0.01).
conclusionThis study, based on a tertiary care cohort, confirms alcohol as the leading cause of cirrhosis among hospitalized patients but also highlights a significant burden of viral hepatitis. The high proportion of patients presenting with decompensated disease underscores the critical need for enhanced community-level screening and early intervention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.