ArticleCureus2025
Microwave-Assisted Green Synthesis of Highly Crystalline Copper-Doped ZnO Nanoparticles: Enhanced Antimicrobial and Antifibrotic Effects for Wound Healing.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWound healing involves controlled proliferation of fibroblasts and synthesis of extracellular matrix (ECM). Imbalance in this process leads to excessive fibroblast activity, collagen deposition, and fibrosis. Current pharmacological therapies target the inhibition of profibrotic signaling pathways, and surgical procedures are reserved for advanced pathologic conditions, necessitating research on local therapies. The present study focuses on investigating the antifibrotic potential of Cu-doped ZnO (Cu-ZnO) nanoparticles (NPs) synthesized using a microwave-assisted green synthesis method.
methodsZnO and Cu-ZnO NPs were synthesized utilizing microwave energy using
resultsX-ray diffraction analysis confirmed successful Cu²⁺ incorporation into the ZnO lattice, with distinct (200) and enhanced (101) diffraction peaks and a reduction in crystallite size at higher dopant levels. Morphological assessment revealed a transition from irregularly shaped ZnO NPs to well-defined tripod-like Cu-ZnO nanoforms, indicating directional growth. UV-Visible (UV-Vis) spectroscopy showed a red shift, reflecting the narrowing of the band gap upon Cu doping. Antimicrobial evaluation against
conclusionsCu-ZnO NPs exhibited strong antimicrobial activity, maintained hemocompatibility, and effectively regulated the proliferation of the fibroblasts. The enhanced antifibrotic effect is mainly driven by elevated ROS levels, which induce mitochondrial membrane depolarization, as confirmed by the JC-1 assay, leading to mitochondrial stress and apoptotic elimination of hyperproliferative fibroblasts.
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Registered trials
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