ArticleFrontiers in public health2025
Multiple Chemical Sensitivity: an Italian prevalence multicentric survey.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute Events and Fatal Outcomes Following Exposure to Volcanic Gases (SOMedical sciences (Basel, Switzerland) · 2026Pooled it
- Where Environment and Healthcare Meet: Air Pollution, Antibiotic Use, and Mortality in an Ageing Population in Southern Italy.Medical sciences (Basel, Switzerland) · 2026Article
- Prevention as a Pillar of Communicable Disease Control: Strategies for Equity, Surveillance, and One Health Integration.Epidemiologia (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multiple Chemical Sensitivity (MCS) is a multisystem environmental disorder triggered by exposure to chemical agents at concentrations below toxicological thresholds. Despite controversy surrounding its classification, MCS is increasingly recognized for its significant impact on health and quality of life. This study aims to evaluate the prevalence, symptomatology, and risk factors associated with MCS in the general population, using the Quick Environmental Exposure and Sensitivity Inventory (QEESI) as a diagnostic tool. Methods: A multicenter retrospective study was conducted on 494 adults. Participants completed the QEESI questionnaire, and data were analyzed for clinical correlations, laboratory findings, environmental exposures, and socio-demographic characteristics. Results: The analysis revealed that 5.7% of the population exhibited symptoms compatible with MCS. Notably, 1.4% reported changes in work or residence due to receiving an allergic or rheumatologic diagnosis. Strong associations were identified between MCS-related symptoms and exposures such as food preservatives, colorings, Wi-Fi, and chemicals the condition: Symptom severity scoring was high in 15.8% of participants, while chemical intolerance was high in 86.4%. A total of 15.5% underwent further diagnostic evaluations, with 21.4% agents. Statistical analysis highlighted correlations between MCS symptom severity and variables such as chemical intolerance, hyperosmia, hypergeusia, and dermatological reactions. Risk profiling classified 10.73% of participants as highly suggestive of MCS. Conclusion: This study confirms the presence of MCS symptoms in 5.7% of the population and highlights that a significant portion, with 10.73% being classified as "very suggestive" and 40.4% as "moderately suggestive" of the condition, may be vulnerable to chemical exposures. The results support the need for standardized diagnostic protocols and multidisciplinary approaches to management.
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