SynthesisFrontiers in public health2025
Prevalence and risk factors of negative emotions in infertile women: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influencing factors of fertility concerns in cancer patients of childbearing age: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Network structure of depression and anxiety symptoms with psychosocial factors among Chinese women with primary infertility: a multi-center cross-sectional study.BMC psychiatry · 2026Article
- Evaluation of coping mechanisms and depression, anxiety, and stress in women with infertility: A cross-sectional study.International journal of reproductive biomedicine · 2026Article
- Latent Profile Analysis and Predictors of Positive Psychological Capital in Patients Undergoing in vitro Fertilization-Embryo Transfer.International journal of women's health · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The purpose of this study was to investigate the prevalence of anxiety and depression in female infertility patients, as well as the risk factors that are linked to these conditions, through a systematic review and meta-analysis. Methods: Eight databases-PubMed, Web of Science, Embase, Cochrane Library, Sinomed, CNKI, VIP, and WanFang-were thoroughly searched, with the search period lasting until February 28, 2025. Research on anxiety or depression and the risk factors linked to it that involved female infertility patients was included. Information was taken from each study, including study region, patient age, prevalence rates, and risk factors for anxiety or depression in female infertility patients. Results: It was discovered that 41% [95% CI (0.35, 0.47)] of female infertility patients had anxiety, and 42% [95% CI (0.36, 0.48)] had depression. Age [OR = 1.38, 95% CI (1.10, 1.73)], duration of infertility [OR = 1.68, 95% CI (1.30, 2.17)], treatment expenses [OR = 2.04, 95% CI (1.78, 2.34)], and lack of knowledge about Assisted Reproductive Technology (ART)-related Information [OR = 1.70, 95% CI (1.26, 2.29)] were significantly associated with anxiety. Age [OR = 1.16, 95% CI (1.00, 1.33)], duration of infertility [OR = 1.83, 95% CI (1.56, 2.16)], treatment expenses [OR = 1.47, 95% CI (1.25, 1.74)], history of miscarriage [OR = 2.17, 95% CI (1.43, 3.31)], and primary infertility [OR = 2.15, 95% CI (1.55, 3.00)] were risk factors for depression. Other factors analyzed, such as place of residence, no reproductive history, and family income, were not found to be statistically significant. Conclusion: Women with infertility face a high incidence of anxiety and depression, which is related to factors such as treatment costs, age, and duration of infertility. A history of miscarriage or primary infertility further increases the risk of depression, while a lack of knowledge of assisted reproductive technologies increases the risk of anxiety. Systematic review registration: PROSPERO, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251036068.
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