ArticleFrontiers in medicine2025
Perioperative nursing coordination and complication management in Yttrium-90 radioactive microsphere therapy for hepatocellular carcinoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To explore the perioperative nursing protocols and complication management strategies for hepatocellular carcinoma (HCC) patients undergoing Yttrium-90 (Y-90) radioactive microsphere therapy. Methods: A retrospective analysis was performed on clinical data from 15 HCC patients treated with Y-90 radioactive microspheres at Qilu Hospital of Shandong University between December 2024 and April 2025. A structured, multidisciplinary perioperative nursing protocol was implemented, consisting of: (1) Preoperative multidisciplinary evaluation including nutritional risk screening (NRS-2002), radiation dosimetry assessment, and vascular anatomy verification; (2) Intraoperative coordination with specific steps for patient positioning, vascular access establishment, radiation safety measures, and vital sign monitoring; (3) Postoperative dynamic monitoring of vital signs (every 2 h), puncture site condition, laboratory parameters (at 24 and 72 h), and symptom assessment using NRS for pain; (4) Tiered complication management system based on CTCAE v5.0 grading criteria. All 15 patients completed the treatment successfully. The postoperative complication rate was 73.3% (11/15), with manifestations including abdominal pain (five cases), fatigue (three cases), leukopenia (three cases), thrombocytopenia (two cases), and low-grade fever (one case), all complications resolved with appropriate symptomatic management. No severe adverse events such as radiation-induced liver injury or significant myelosuppression occurred. Standardized perioperative nursing workflows, comprehensive radiation protection protocols, and an early-warning system for complications are essential to enhancing the safety of Y-90 microsphere therapy.
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