Evidence map›Paper›PMID 41426584›Full record

ArticleFrontiers in medicine2025

Zinc oxide nanoparticle chelated phosphocreatine-grafted chitosan composite hydrogels for enhancing osteogenesis and angiogenesis in bone regeneration.

Leidong Lian, Dingli Xu, Chaonan He, Zhe Luo, Han Yu, Botao Liu, Ke Zhou, Liangjie Lu, Kaifeng Gan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Leidong Lian *The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Dingli Xu *Health Science Center, Ningbo University, Ningbo, China.
Chaonan HeNingbo Institute of Innovation for Combined Medicine and Engineering, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zhe LuoThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Han YuHealth Science Center, Ningbo University, Ningbo, China.
Botao LiuHealth Science Center, Ningbo University, Ningbo, China.
Ke ZhouThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Liangjie LuThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Kaifeng GanThe Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The natural polysaccharide-based injectable hydrogels have showed significant interest to use as 3D scaffolds for critical-sized bone defect repair. Methods: Here, we incorporated ZnO nanoparticles (NPs) into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an injectable hydrogel (CSMP-ZnO) via supramolecular combination between phosphate groups in CSMP and Zinc in ZnO NPs. Results: The phosphocreatine in this hydrogel not only provides sites to combine with ZnO NPs form supramolecular binding but also serves as the reservoir to control Zn Discussion: Both the

Indexed as

bone regenerationchitosanosteogenesisphosphate-functionalizedzinc oxide nanoparticles

Identifiers

PMID41426584
PMCPMC12714965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.