ArticleFrontiers in medicine2025
Cervical pregnancy treated with methotrexate combined with traditional Chinese medicine: a case report and literature review.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cervical pregnancy is a rare form of ectopic pregnancy in which the embryo implants within the cervical canal. With the growing use of assisted reproductive technologies (ARTs), its incidence has gradually increased. Traditionally, management often necessitated hysterectomy due to the high risk of severe hemorrhage. However, conservative approaches using methotrexate (MTX), either alone or in combination with adjunctive therapies, have demonstrated success in preserving fertility. Case presentation: We present the case of a 38-year-old woman who presented with amenorrhea and prolonged vaginal bleeding. Ultrasonography and elevated serum beta-human chorionic gonadotropin (β-hCG) levels confirmed the diagnosis of cervical pregnancy. The patient was treated with systemic MTX (50 mg/m Conclusion: Combined therapy with MTX and TCM may provide an effective, fertility-preserving option for carefully selected patients with cervical pregnancy. TCM may enhance the efficacy of MTX, facilitate tissue resorption, and reduce drug toxicity. Further research is warranted to standardize herbal dosages and clarify the underlying pharmacological mechanisms.
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