ArticleFrontiers in medicine2025
The role of systemic immune-inflammation index in differentiation of juvenile idiopathic arthritis from reactive arthritis among Chinese children.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The study aims to evaluate the diagnostic value and clinical significance of the Systemic Immune-Inflammation Index (SII) in differentiating juvenile idiopathic arthritis (JIA) from reactive arthritis (ReA) in Chinese children aged under 18. Methods: This study conducted a retrospective analysis of 865 arthritis patients treated at Capital Children's Medical Center Affiliated to Capital Medical University between January 2020 and January 2025. Spearman correlation analysis was used to assess the relationship between SII and inflammatory biomarkers. Logistic regression analysis was performed to assess the independence of SII in JIA diagnosis, and the diagnostic performance was evaluated using receiver operating characteristic (ROC) curves. Results: The diagnostic performance for differentiating JIA from ReA was evaluated using ROC curves. The area under the curve (AUC) values were as follows: SII (AUC = 0.83), c-reactive protein (CRP) (AUC = 0.81), erythrocyte sedimentation rate (ESR) (AUC = 0.78), hemoglobin (Hb) (AUC = 0.75). To statistically compare these AUC values, we implemented the DeLong test. The DeLong test results showed that the AUC of SII was significantly higher than that of CRP ( Conclusion: The SII values in JIA patients are higher than those in ReA and are associated with disease activity. This suggests that SII is applicable for early differential diagnosis between these two types of arthritis.
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