SynthesisFrontiers in medicine2025
Effectiveness and safety of ultrasound-guided needle-knife therapy for patients with spinal pain disorders: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Toward visualized pathophenotyping: a multimodal imaging-guided conceptual framework for chronic low back pain.Frontiers in medicine · 2026Article
- Efficacy and Safety of Ultrasound-Guided Acupotomy for Chronic Spinal Musculoskeletal Pain: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Requirements for the development of pre-surgical therapies for spinal pain disorders have arisen, with ultrasound-guided needle-knife therapy (US-NKT) gaining popularity as a minimally invasive treatment. This study aimed to evaluate the clinical outcomes of US-NKT, focusing on its effectiveness and safety. Methods: A comprehensive literature survey was conducted by using 12 databases to identify randomized controlled trials (RCTs) comparing the effects of US-NKT with control in patients with spinal pain disorders. Characteristics of RCTs were extracted. Also, a meta-analysis of pain and physical function (PF) outcomes was performed at 1-week, 1-month, and 3-month follow-ups. Adverse events (AEs) were also analyzed. Results: Of the 1,694 articles screened, 23 RCTs ( Conclusion: US-NKT demonstrates superior efficacy in reducing pain and improving PF compared with recommended therapies or conventional NKT, with a favorable safety profile. However, sustained benefits beyond 3 months remain inconclusive. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024529315.
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Registered trials
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