ArticleFrontiers in sleep2023
Sleep apnea endotypes: from the physiological laboratory to scalable polysomnographic measures.
Article in Frontiers in sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Real-world generalizability of sleep apnea-related polysomnographic metrics and their associations with clinical comorbidities.Annals of the American Thoracic Society · 2026Article
- Molecular Drivers of Cognitive Decline and Neuroprotection in Obstructive Sleep Apnea: A Narrative Review.Antioxidants (Basel, Switzerland) · 2026Review
- Predicting optimal CPAP pressure in obstructive sleep apnea among Chinese patients using respiratory endotype derived from polysomnography.Scientific reports · 2026Article
- Current Updates on Pharmacotherapy for Obstructive Sleep Apnea.Journal of rhinology : official journal of the Korean Rhinologic Society · 2026Review
- Distinguishing Age-specific Patterns in Comorbidities of Obstructive Sleep Apnea Using Real-World Data.medRxiv : the preprint server for health sciences · 2026Article
- CPAP Therapy Linked False Reassurance to Obstructive Sleep Apnea Patients: A Retrospective Observational Study.Integrative medicine (Encinitas, Calif.) · 2026Article
- Endotypic traits and lung function in patients with obstructive sleep apnea comorbid with obesity hypoventilation syndrome.Sleep & breathing = Schlaf & Atmung · 2026Article
- Treatment choice in mild to moderate sleep apnoea in the European Sleep Apnea Database.ERJ open research · 2025Article
- Reduction of carbonic anhydrase activity is associated with amelioration of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- ERS Congress 2024: highlights from the Sleep Disordered Breathing Assembly.ERJ open research · 2025Article
- Article
- Research Accomplishments in Pulmonary, Critical Care, and Sleep: A Retrospective Review.American journal of respiratory and critical care medicine · 2023Article
- Translation of obstructive sleep apnea pathophysiology and phenotypes to personalized treatment: a narrative review.Frontiers in neurology · 2023Review
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Authors and funding
10 authors.
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Abstract
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent upper airway obstruction during sleep. Despite the availability of continuous positive airway pressure (CPAP) as the gold standard treatment, it is not well tolerated by all patients. Accordingly, research has increasingly focused on developing methods for OSA endotyping, which aims to identify underlying pathophysiological mechanisms of the disorder to help guide treatment for CPAP-intolerant individuals. Four key endotypic traits have been identified, namely: collapsibility, upper airway muscle compensation, arousal threshold and loop gain. However, most methods for extracting these traits require specialized training and equipment not available in a standard sleep clinic, which has hampered the ability to assess the full impact of these traits on OSA outcomes. This paper aims to provide an overview of current methods for OSA endotyping, focusing on the Endo-Phenotyping Using Polysomnography (PUP) method and its cloud-based extension, PUPpy, which offer scalable and accessible ways to estimate endotypic traits from standard polysomnography. We discuss the potential for these methods to facilitate precision medicine for OSA patients and the challenges that need to be addressed for their translation into clinical practice.
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