ArticleFrontiers in psychology2025
Cross-frequency coupling patterns during oddball processing in disorders of consciousness: a delta-gamma predominance.
Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Phase-amplitude coupling (PAC) between low- and high-frequency oscillations provides a candidate mechanism for integrating information across cortical networks. While PAC alterations have been reported in disorders of consciousness (DOC), the frequency specificity and task dependence of these changes remain poorly characterized. Objective: To systematically examine cross-frequency coupling patterns during auditory oddball processing in DOC patients and explore whether specific frequency combinations or frequency shifts are associated with different levels of consciousness. Methods: Sixty-two participants [20 healthy controls (HC), 21 minimally conscious state (MCS), 21 unresponsive wakefulness syndrome (UWS)] underwent EEG recording during an auditory oddball paradigm. PAC was quantified using the Kullback-Leibler modulation index across comprehensive frequency ranges (phase: 1-31 Hz; amplitude: 8-77 Hz) without strong Results: Delta-gamma coupling (1-4 Hz phase) dominated across all groups, with delta-gamma PAC consistently and significantly exceeding theta-gamma, alpha-gamma and beta-gamma coupling (all Conclusion: Auditory oddball processing preferentially engages delta-gamma, rather than theta-gamma, coupling in both healthy individuals and DOC patients, supporting the view that PAC signatures are task- and paradigm-specific rather than universal markers of consciousness. Within this framework, a non-significant tendency towards frequency slowing and a reduction in PAC variability in UWS emerge as preliminary, hypothesis-generating features that warrant further investigation in larger, longitudinal and multi-paradigm cohorts.
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