Evidence map›Paper›PMID 41426343›Full record

ReviewFrontiers in oncology2025

Rewiring immune evasion in liver metastases: WNT11 as a central node - a mini review.

Xiaoling Wang, Youcai Huang, Tingting Luo, Qinxian Liu, Yu Tian, Xiaoyu Hu, Yi Zheng, Shumin Fang, Yanyang Tu, Haining Zhen and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoling Wang *Science Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Youcai Huang *Science Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Tingting Luo *Science Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Qinxian LiuScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Yu TianScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Xiaoyu HuScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Yi ZhengScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Shumin FangScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Yanyang TuScience Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Haining ZhenDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xian, China.
Yu GuoZhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver metastasis (LM) poses a formidable barrier to effective immunotherapy, largely due to its uniquely immunosuppressive microenvironment and resistance to immune checkpoint blockade (ICB).Among emerging mechanisms, WNT11, a non-canonical WNT ligand, has been identified as a preclinical modulator of immune evasion in LM. Acting through a calcium-dependent CAMKII signaling pathway axis, WNT11 suppresses CD8

Indexed as

CaMKII signalingimmune checkpoint blockade resistanceliver metastasistumor immune microenvironmentWnt11

Identifiers

PMID41426343
PMCPMC12711467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.