SynthesisFrontiers in oncology2025
Relationship between preoperative plasma fibrinogen and prognosis in patients with non-metastatic gastric cancer: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Preoperative hypoalbuminemia as a prognostic factor in patients with gastric cancer undergoing radical gastrectomy: Construction of a nomogram.The Journal of international medical research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preoperative plasma fibrinogen (Fib) is a potential prognostic marker for various cancers, including gastric cancer. This systematic review and meta-analysis aimed to investigate the relationship between preoperative fibrinogen levels and prognosis in patients with non-metastatic gastric cancer patients. Methods: This meta-analysis was conducted in accordance with the PRISMA guidelines. A comprehensive literature search of PubMed, Embase, Web of Science, and Cochrane Library was performed up to May 26, 2025, without language or date restrictions. Eligible studies reported multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) and recurrence-free survival (RFS) in relation to preoperative fibrinogen levels. Subgroup and sensitivity analyses were performed, and study quality was assessed using the Newcastle-Ottawa Scale (NOS). Results: A total of 8 retrospective studies involving 4,281 patients were included. Pooled analysis revealed that elevated fibrinogen levels were significantly associated with poorer OS (HR = 1.56, 95% CI: 1.20-1.93, P < 0.001; I² = 57.0%) and RFS (HR = 2.08, 95% CI: 1.33-2.82, P < 0.001; I² = 0%). Subgroup analyses confirmed consistent associations across age, sex, tumor stage, geographic region, and fibrinogen cut-off values. No significant publication bias was detected. Conclusions: Elevated preoperative fibrinogen levels are significantly associated with worse overall and recurrence-free survival in patients with non-metastatic gastric cancer, indicating its potential utility as a prognostic biomarker. Given the limited data on RFS, further large-scale prospective studies are needed to validate these findings and support its integration into individualized risk stratification models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.