ArticleAdvances in virology2025
Molecular Characterization and Genomic Diversity of SARS-CoV-2 Spike Gene Variants Circulating in Iraq: Mutational Impact on ACE2 Affinity, RBD Immune Escape, and Viral Transmission.
Article in Advances in virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Authors and funding
6 authors.
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Abstract
Introduction: The spike (S) gene of SARS-CoV-2 is pivotal to the processes of cell entry, immune evasion, and the adaptation of the host. Aim: This study aimed to comprehensively characterize the SARS-CoV-2 spike gene variants circulating in Iraq and assess the functional consequences of their mutations on ACE2 receptor affinity, RBD-mediated immune escape, and viral transmissibility. It represents the first integrative genomic and functional profiling of Iraqi SARS-CoV-2 spike variants, providing novel regional insights into viral adaptation and evolution. Methods: Whole-genome sequencing was performed on Iraqi SARS-CoV-2 isolates, followed by mutation profiling, phylogenetic classification, and comparison with global datasets. Key spike mutations- Results: Iraqi isolates clustered mainly within the Conclusion: The absence of
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