ArticleFrontiers in human neuroscience2025
Transcranial magnetic stimulation to probe the role of the supplementary motor area in tics.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Supplementary motor area (SMA) hyperactivity is thought to be a key neural mechanism in tics. This study probed SMA's role in tic expression, voluntary tic control, and premonitory urge experiences using one session of 1 Hz "inhibitory" repetitive transcranial magnetic stimulation (rTMS) targeting SMA in a repeated measures, small-N experimental design. Methods: Youth with Tourette Syndrome (TS) ages 12-17 years ( Results: Active rTMS led to greater tic frequency reductions during Free-to-Tic ( Discussion: Overall, results suggest that the acute aftereffects of active 1 Hz rTMS to SMA may include reduced natural tic frequency, improved tic controllability, and lower urge intensity, especially while engaged in suppression efforts. Results are consistent with prior literature pointing to SMA hyperactivation in TS and suggests the potential therapeutic value of rTMS.
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