ArticleInfection and drug resistance2025
Seasonal Genomic Dynamics of Multidrug-Resistant Pathogens in ICU Environments and Perspectives on Phage-Based Interventions.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microbiological Profile and Antimicrobial Resistance Patterns in an Intensive Care Unit: Emphasis on ESKAPE Pathogens.Antibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Background: The emergence of multidrug-resistant (MDR) pathogens in intensive care units (ICUs) has become a pressing global health issue, contributing to mortality rates exceeding 40%. Among these, carbapenem-resistant Objective: This study investigated the seasonal variation in resistance gene prevalence among ICU-derived bacterial isolates and elucidates the genomic features contributing to antimicrobial resistance. Methods: Environmental and clinical samples were collected from ICU settings over multiple seasons using a systematic, stratified approach. Whole-genome sequencing was conducted on isolates via Illumina and Nanopore platforms. Resistance genes were annotated using CARD, VFDB, and BiocideResistance databases. Statistical associations were assessed using logistic regression and generalized linear mixed models, while phylogenetic trees evaluated clonal relationships. Results: The bla Conclusion: This study reveals distinct seasonal genomic patterns in ICU drug-resistant pathogens and emphasizes the necessity for adaptive infection control strategies. Targeted disinfection, antibiotic stewardship, and consideration of phage therapy as a complementary strategy particularly during winter may help mitigate the spread of high-risk resistant clones, though further in vitro and in vivo validation is required.
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