ArticleKidney international reports2025
Mass Spectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis.
Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Steroid-Resistant Idiopathic Nephrotic Syndrome Reveals a Distinct Maladaptive Molecular State.Kidney international reports · 2026Article
- Integrating Tissue Proteomics and Urinary Analyses to Capture Dynamic Podocyte Injury.Kidney international reports · 2026Article
- Response to the Letter to the Editor Entitled "Integrating Tissue Proteomics and Urinary Analysis to Capture Dynamic Podocyte Injury".Kidney international reports · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The relation between minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) (pFSGS) remains debatable, and the recent discovery of antinephrin and antislit antibodies, supports the hypothesis of a continuum disease. However, the overall expression of podocyte proteins in these disease states is not known. Methods: In this observational proteomic study, we used laser microdissection and mass spectrometry (LMD/MS) to determine the proteomic profile of podocyte proteins in kidney biopsies of adult patients with MCD ( Results: LMD/MS show moderate baseline total spectrum of podocyte proteins, NPHS1, NPHS2, CD2-associated protein, alpha-actinin-2, inverted formin-2 (INF2), and dystroglycan 1 (DAG1) in T0 and MN controls. In contrast, there was a significant loss of all 6 podocyte proteins in MCD, pFSGS, sFSGS, and gFSGS but not in MN cases. IF staining confirmed podocyte loss of NPHS1 and NPHS2 in MCD, pFSGS, sFSGS, and gFSGS but not in T0 or MN. Conclusion: LMD/MS and IF staining show significant and comparable loss of podocyte proteins involving the slit diaphragm and actin cytoskeleton in MCD, pFSGS, sFSGS, and gFSGS suggesting a common final pathway of podocyte injury. Surprisingly, despite similar degrees of proteinuria, MN was not associated with significant loss of podocyte proteins.
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