Evidence map›Paper›PMID 41426025›Full record

ArticleKidney international reports2025

Furosemide Stress Test Use in Children at Risk for Acute Kidney Injury.

Imogen Clover-Brown, Giovanni Ceschia, Katja M Gist, Denise C Hasson, Kelli A Krallman, Stephen W Standage, Stuart L Goldstein, Natalja L Stanski

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07718464 (Furosemide Stress Test Implementation and Outcomes in Critically Ill Children at High Risk for Acute Kidney Injury), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07718464 recruitingnot on this mapstarted 2026, after this paper: background citation

Furosemide Stress Test Implementation and Outcomes in Critically Ill Children at High Risk for Acute Kidney Injury: A Hybrid Study

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2026 to 2028Enrolled120ConditionsAcute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care UnitArmsFurosemide Stress Test Clinical Decision Support Tool
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Preventing pediatric acute kidney injury: is it even possible?Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Imogen Clover-BrownDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Giovanni CeschiaCenter for Acute Care Nephrology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Katja M GistDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, Colorado, USA.
Denise C HassonDepartment of Pediatrics, Hassenfeld Children's Hospital at New York University Langone Health, New York, New York, USA.
Kelli A KrallmanCenter for Acute Care Nephrology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Stephen W StandageDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Stuart L GoldsteinCenter for Acute Care Nephrology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Natalja L StanskiDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Funding

Proteomics CoreP50DK096418 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI DEVARAJAN, PRASAD · 2012 to 2021
$8.4M
Developing a Precision Medicine Approach to Pediatric Sepsis-Associated Acute Kidney Injury: Identification of Unique Subphenotypes and Strategies for Bedside ImplementationK23GM151444 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Natalja L. Stanski · 2023 to 2026
$769k
NIDDK NIH HHS P50 DK096418NIGMS NIH HHS K23 GM151444
6 · The paper itself

Abstract

Introduction: The furosemide stress test (FST) is used to assess urine flow rate (UFR) after a furosemide bolus. FST predicts severe acute kidney injury (AKI) and renal replacement therapy (RRT) receipt in adults, with limited data in pediatric intensive care unit (PICU) patients. We implemented AKI risk stratification using the renal angina index (RAI) with urine neutrophil gelatinase-associated lipocalin (uNGAL) to guide FST in high-risk children but have not evaluated outcomes. Methods: We combined 2 prospective, observational studies of high AKI risk PICU patients (RAI+: ≥ 8, uNGAL+: ≥ 150 ng/ml). We compared patients who underwent FST (≥ 0.75 mg/kg i.v. furosemide) in the first week versus those who did not, and FST responders (≥ 3 ml/kg/h UFR over 4 hours) versus nonresponders. We examined UFR's predictive performance for new or persistent severe AKI or RRT receipt 2 days later. Results: Of 273 RAI+/uNGAL+ patients, 112 (41%) underwent FST, 60 (54%) were nonresponders. FST patients had higher admission uNGAL and AKI stage. Nonresponders received FST earlier, had higher AKI stage, and higher incidence of new or persistent severe AKI (89% vs. 37%, Conclusion: FST is used inconsistently in high AKI risk children but has prognostic utility for new or persistent severe AKI, including RRT receipt, independent of AKI stage.

Indexed as

acute kidney injurychildrenfurosemide stress testrenal replacement therapy

Identifiers

PMID41426025
PMCPMC12712464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.