Evidence map›Paper›PMID 41426011›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Cheng's Juanbi Decoction Inhibits Rheumatoid Arthritis Pathology by Blocking the WTAP-Wnt7b-Wnt/β-Catenin Signaling Axis].

Yajie Wu, Wenbo Xu, Meiling Yuan, Xinyue Zhou, Yikang Cai, Huibo Cao, Qiangjun Duan, Tongxiang Tao, Chenggui Miao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yajie Wu（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.ORCID 0009000938004799
Wenbo Xu（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Meiling Yuan（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Xinyue Zhou（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Yikang Cai（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Huibo Cao（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Qiangjun Duan（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Tongxiang Tao（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.
Chenggui Miao（ 230012） Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.ORCID 0000000178624524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Cheng's Juanbi Decoction (CSJBD) is a classic traditional Chinese medicine formula for treating rheumatoid arthritis (RA), exhibiting significant clinical efficacy, but the underlying mechanisms remain unclear. We investigated whether CSJBD inhibited RA pathology by blocking the WTAP-Wnt7b-Wnt/β-catenin signaling axis using a collagen-induced arthritis (CIA) mouse model and fibroblast-like synoviocytes (FLSs) derived from RA patients (RA FLSs) and examined the underlying mechanisms. Methods: We conducted Results: According to the UPLC analysis, ferulic acid, osthole, mulberroside A, notopterol, and gentiopicroside were identified as quality control standards for the preparation of CSJBD formula. CSJBD improved RA pathology in CIA mice, reduced the levels of interleukin (IL)-6, IL-1β, IL-8, and tumor necrosis factor-α (TNF-α) in their serum, and decreased the expression of RA pathological genes Conclusion: CSJBD inhibits RA pathology by blocking the WTAP-Wnt7b-Wnt/β-catenin signaling axis, with Wnt7b identified as a direct therapeutic target of CSJBD.

Indexed as

Arthritis, ExperimentalArthritis, Rheumatoidbeta CateninDrugs, Chinese HerbalWnt ProteinsWnt Signaling PathwayAnimalsFrizzled-Related ProteinsHumansIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLSynoviocytesbeta CateninDrugs, Chinese HerbalFrizzled-Related ProteinsIntracellular Signaling Peptides and ProteinsWNT7B protein, humanWnt ProteinsCheng's Juanbi DecoctionRheumatoid arthritisWnt7bWnt/β-catenin signaling pathwayWTAP

Identifiers

PMID41426011
PMCPMC12712374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.