ArticleFrontiers in cardiovascular medicine2025
Impact of factor V Leiden on outcomes following coronary artery bypass grafting: a national inpatient sample analysis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Coronary artery bypass grafting (CABG) is commonly used for revascularization in patients with advanced coronary artery disease. Factor V Leiden (FVL) is a hereditary hypercoagulable state in which factor V is resistant to activation by activated protein C, causing activation of prothrombin and an increased propensity for thrombotic events. In this study, we aim to establish whether FVL increases in-hospital mortality following a CABG procedure. Methods: The National Inpatient Sample was used to extract data on patients who underwent a CABG procedure between 2017 and 2022. Patients were grouped based on a diagnosis of FVL ( Results: A higher proportion of patients with FVL were female ( Conclusions: FVL is not associated with increased risk of in-hospital mortality following a CABG procedure. This finding can help guide providers considering CABG for revascularization in patients with FVL.
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