ArticleFrontiers in cellular and infection microbiology2025
Cytokine dynamics in the blood and cerebrospinal fluid of HIV/AIDS patients with cryptococcal meningitis receiving antifungal therapy.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cytokines in the serum and cerebrospinal fluid (CSF) are critical to the pathogenesis of HIV-associated cryptococcal meningitis (HCM). Previous studies focused on baseline cytokine levels, but changes during antifungal therapy are underexplored. Methods: Twenty-three patients with a first episode of HCM were prospectively followed to evaluate immune cell and cytokine dynamics during antifungal treatment therapy. Clinical features and laboratory data were systematically collected, and principal component and correlation analyses were performed to identify immune factors associated with HCM. Results: Typical clinical manifestations include fever, headache, and nausea, among others. All patients presented severely low CD4 Conclusion: Cytokines derived from innate immune cells play a central role in host defense against HIV-associated cryptococcal infections. The observed reductions in cytokine levels in both plasma and CSF after antifungal therapy provide new insights into the immune response in HCM, highlighting the dynamic interplay of immune factors during treatment.
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