Association between red blood cell distribution width coefficient of variation and post-treatment bilirubin decline velocity in neonatal hyperbilirubinemia.

Hongjuan Wei, Tingting Zhang, Rufeng Ji, Yinyan Tang

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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Hongjuan Wei *Department of Pediatrics, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Tingting Zhang *Department of Pediatrics, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Rufeng JiDepartment of Pediatrics, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Yinyan TangDepartment of Pediatrics, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.

Funding

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6 · The paper itself

Abstract

Background: Red blood cell distribution width coefficient of variation (RDW-CV) reflects erythrocyte heterogeneity, but its correlation with posttreatment bilirubin kinetics in neonatal hyperbilirubinemia (NHB) remains underexplored. Methods: This cross-sectional study analyzed 803 neonates (≥35 weeks of gestation) with NHB. RDW-CV was measured at admission, and bilirubin decline velocity was calculated during phototherapy. Associations were evaluated using multivariate linear regression and restricted cubic splines, adjusted for demographic, maternal, and hematologic factors. Results: Each 1% RDW-CV increase independently reduced bilirubin decline velocity by 2.04 μmol/(L·day) ( Conclusions: RDW-CV is an independent predictor of bilirubin clearance in NHB, exhibiting a linear dose-response effect. These findings highlight its potential as a biomarker for phototherapy stratification.

Indexed as

bilirubin decline velocityhemolytic disease of newbornneonatal hyperbilirubinemiaphototherapy efficacyred blood cell distribution width

Identifiers

PMID41425893

DOI10.3389/fped.2025.1690164

PMCPMC12711753

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