ArticleFrontiers in pediatrics2025
Predictive value of Th17/Treg immune imbalance for disease severity and poor prognosis in children with respiratory syncytial virus pneumonia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic potential of nutritional aryl hydrocarbon receptor ligands for respiratory syncytial virus infection: a mini review.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Respiratory syncytial virus pneumonia (RSVP) remains a major cause of pediatric hospitalization. This study evaluates the value of Th17/Treg imbalance in assessing disease severity and predicting prognosis among RSVP children. Methods: RSVP children (422 cases) during May 2022-May 2024 were retrospectively enrolled and divided into mild and moderate-to-severe groups based on disease severity. Additionally, 358 healthy children were recruited (the control group). Peripheral blood Th17 and Treg cell proportions were quantified by flow cytometry, with the Th17/Treg ratio calculated. Serum IL-17, IL-6, IL-10, and TGF-β1 levels were measured using ELISA. Logistic regression models were established to identify risk factors for poor prognosis. ROC curves were plotted to evaluate predictive performance. Results: RSVP children demonstrated higher Th17 cell proportion, IL-17 and IL-6 levels, and Th17/Treg ratio than controls, alongside lower Treg cell proportion and IL-10 and TGF-β1 levels (all Conclusion: Peripheral blood Th17/Treg imbalance is a characteristic of RSVP children. The combined detection of Th17/Treg ratio, IL-17, and IL-10 can help predict poor prognosis in affected children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.