ArticleInternational journal of genomics2025
CLDN22 Serves as a Novel Prognostic Biomarker and Immunotherapy Response Predictor in Gliomas: A Comprehensive Multiomics Analysis.
Article in International journal of genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- CLDN22 Serves as a Novel Prognostic Biomarker and Immunotherapy Response Predictor in Gliomas: A Comprehensive Multiomics Analysis.International journal of genomics · 2025Article
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Authors and funding
7 authors.
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Abstract
Background: The claudin gene family plays crucial roles in cancer biology, yet their comprehensive molecular characteristics and clinical implications in gliomas remain unclear. Methods: Multiomics data from The Cancer Genome Atlas (TCGA) were analyzed, and differential expression analysis was performed between glioma and normal samples. Consensus clustering was applied to identify molecular subtypes. Multiple machine learning algorithms, including least absolute shrinkage and selection operator (LASSO), extreme gradient boosting (XGBoost), Boruta, prediction analysis of microarrays (PAMR), and random forest, were employed for feature selection. Immune characteristics were evaluated using Estimation of STromal and Immune cells in MAlignant Tumors using Expression data (ESTIMATE), cell-type enrichment analysis by gene expression signatures (xCell), and Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) algorithms. Drug sensitivity analysis was conducted using the Genomics of Drug Sensitivity in Cancer (GDSC) database. Functional enrichment analysis was performed based on Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results: We identified distinct regulatory patterns of claudin family genes involving CNV and DNA methylation. Consensus clustering revealed two molecular subtypes with significant differences in survival ( Conclusion: Our comprehensive analysis establishes CLDN22 as a novel prognostic and predictive biomarker in gliomas with significant implications for patient stratification and therapeutic decision-making. These findings provide new insights into glioma biology and potential therapeutic strategies, though further experimental validation is warranted.
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