Evidence map›Paper›PMID 41425785›Full record

ArticleCJC open2025

The Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) Trial-IMAGE HF Project 1A.

Lisa M Mielniczuk, Eileen O'Meara, Christiane Wiefels, Li Chen, Linda Garrard, James White, Robert A deKemp, Marcelo F Di Carli, Eric Larose, David I Paterson and 16 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01288560 (Alternative Imaging Modalities in Ischemic Heart Failure), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01288560 nacompletednot on this map

Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) Project I-A of Imaging Modalities to Assist With Guiding Therapy and the Evaluation of Patients With Heart Failure (IMAGE-HF)

TypeinterventionalSponsorOttawa Heart Institute Research CorporationRan2011 to 2022Enrolled1,390ConditionsHeart Failure, Coronary Artery Disease, Ischemic CardiomyopathyArmsAdvanced cardiac imaging, Standard Cardiac Imaging
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lisa M MielniczukDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Eileen O'MearaInstitut de Cardiologie de Montréal, Université de Montreal, Montreal, Quebec, Canada.
Christiane WiefelsDivision of Nuclear Medicine, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Li ChenCardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Linda GarrardDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
James WhiteLibin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Robert A deKempDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Marcelo F Di CarliDivision of Nuclear Medicine and Molecular Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Eric LaroseInstitut Universitaire de Cardiologie et de Pneumologie de Quebec, Department of Medicine, Université Laval, Laval, Quebec, Canada.
David I PatersonDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Justin EzekowitzCanadian VIGOUR Centre, Division of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
Riina M KandolinHelsinki University Central Hospital, Helsinki, Finland.
Graham WrightSunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Roxana CampisiInstituto Argentino de Diagnóstico y Tratamiento S.A. and Diagnóstico Nuclear, Buenos Aires, Argentina.
Mika K LaineHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Kim ConnellyKeenan Research centre for Biomedical Science, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Miroslaw RajdaNova Scotia Health Authority, QE II Health Science Center, Halifax, Nova Scotia, Canada.
Joao V VitolaQUANTA Diagnóstico, Curitiba, Brazil.
Serge LepageUniversité de Sherbrooke, Sherbrooke, Quebec, Canada.
Juha HartikainenDivision of Cardiology, Kuopio University Hospital Heart Centre, Kuopio, Finland.
Benjamin ChowDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Anahita TavoosiDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Juhani KnuutiTurku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
George A WellsCardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Rob S B BeanlandsDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
IMAGE HF Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of advanced (cardiac magnetic resonance [CMR] or positron emission tomography [PET]) vs single-photon emission computerized tomography (SPECT) ischemia imaging to guide management remains unclear in patients with ischemic heart failure (IHF). The primary aim was to determine the effect of imaging modality on a composite cardiovascular endpoint and cardiac death in patients with IHF who require ischemia assessment. Methods: Patients with IHF were randomized to advanced or SPECT imaging. A parallel registry also was performed. The primary endpoint was the composite of cardiac death, infarction, arrest, and cardiac rehospitalization. The key secondary endpoint was cardiac death. Results: Patients in the randomized population (advanced imaging [PET or CMR; n = 64] or SPECT [n = 56]) had a cumulative incidence rate (CIR) for the primary endpoint of 33.1% and 33.0%, respectively (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.49, 1.80, Conclusion: Among IHF patients assessed for ischemia, advanced imaging (PET or CMR) was not associated with reduced composite cardiac events, compared to SPECT. Clinical Trial Registration: NCT01288560.

Indexed as

cardiac magnetic resonance imagingHeart failureischemic cardiomyopathynuclear cardiologypositron emission tomographyrevascularization

Identifiers

PMID41425785
PMCPMC12713179

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.